1. Caring, and in a way you may not be used to. The people you will be helping are ones you may never meet, and they will suffer from diseases that you and your family will never get. This isn't "all funds go to local______......" Help will go to places where there is no local help.
2. Learning: You will have to learn about Echinococcus granulosus (hydatid disease), Trypanosoma cruzi (Chagas' Disease), and neurocysticercosis. But don't be intimidated--they're fascinating aspects of biology.
3. Asking people for money: Yeah, it sounds like it's horrible, and on occasion it can be. On the other hand, you'll be surprised how easy it can be if you really believe in what you're doing.
(This picture was taken in Sañocc, one of the villages in Santillana where, in conjunction with PRISMA, we built bathrooms in elementary schools.)